Targeting FOXAI-mediated repression of TGF-[beta] signaling suppresses castration-resistant prostate...
Targeting FOXAI-mediated repression of TGF-[beta] signaling suppresses castration-resistant prostate cancer progression
About this item
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Publisher
American Society for Clinical Investigation
Journal title
Language
English
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Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Prostate cancer (PC) progressed to castration resistance (CRPC) is a fatal disease. CRPC tumors develop resistance to new-generation antiandrogen enzalutamide through lineage plasticity, characterized by epithelial-mesenchymal transition (EMT) and a basal-like phenotype. FOXA1 is a transcription factor essential for epithelial lineage differentiati...
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Full title
Targeting FOXAI-mediated repression of TGF-[beta] signaling suppresses castration-resistant prostate cancer progression
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TN_cdi_gale_infotracmisc_A574176409
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A574176409
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI122367
