Adaptive downregulation of Cl.sup.-/HCO.sub.3.sup.- exchange activity in rat hepatocytes under exper...
Adaptive downregulation of Cl.sup.-/HCO.sub.3.sup.- exchange activity in rat hepatocytes under experimental obstructive cholestasis
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Publisher
Public Library of Science
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Language
English
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Public Library of Science
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Contents
In obstructive cholestasis, there is an integral adaptive response aimed to diminish the bile flow and minimize the injury of bile ducts caused by increased intraluminal pressure and harmful levels of bile salts and bilirrubin. Canalicular bicarbonate secretion, driven by the anion exchanger 2 (AE2), is an influential determinant of the canalicular...
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Full title
Adaptive downregulation of Cl.sup.-/HCO.sub.3.sup.- exchange activity in rat hepatocytes under experimental obstructive cholestasis
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TN_cdi_gale_infotracmisc_A575130228
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A575130228
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0212215
