A rare population of tumor antigen-specific CD4+CD8+ double-positive [alpha][beta] T lymphocytes uni...
A rare population of tumor antigen-specific CD4+CD8+ double-positive [alpha][beta] T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells
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Publisher
BioMed Central Ltd
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Language
English
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BioMed Central Ltd
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Contents
Background High-affinity tumor antigen-specific T-cell receptor (TCR) gene is required to engineer potent T cells for therapeutic treatment of cancer patients. However, discovery of suitable therapeutic TCR genes is hampered by the fact that naturally occurring tumor antigen-specific TCRs are generally of low-affinity, and artificial modification o...
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Full title
A rare population of tumor antigen-specific CD4+CD8+ double-positive [alpha][beta] T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells
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Record Identifier
TN_cdi_gale_infotracmisc_A581052473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A581052473
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/s40425-018-0467-y
