PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1.sup.+CD38.sup.hi cells and anti-PD-1...
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1.sup.+CD38.sup.hi cells and anti-PD-1 resistance
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Nature Publishing Group
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English
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Nature Publishing Group
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Understanding resistance to antibody to programmed cell death protein 1 (PD-1; anti-PD-1) is crucial for the development of reversal strategies. In anti-PD-1-resistant models, simultaneous anti-PD-1 and vaccine therapy reversed resistance, while PD-1 blockade before antigen priming abolished therapeutic outcomes. This was due to induction of dysfun...
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Full title
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1.sup.+CD38.sup.hi cells and anti-PD-1 resistance
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TN_cdi_gale_infotracmisc_A597210657
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A597210657
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ISSN
1529-2908
DOI
10.1038/s41590-019-0441-y
