Metabolic targeting of HIF-1[alpha] potentiates the therapeutic efficacy of oxaliplatin in colorecta...
Metabolic targeting of HIF-1[alpha] potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
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Nature Publishing Group
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English
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Nature Publishing Group
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Drug resistance is a major problem limiting the efficacy of chemotherapy in cancer treatment, and the hypoxia-induced stabilization of HIF-1[alpha] plays a role in this process. HIF-1[alpha] overexpression has been observed in a variety of human cancers, including colorectal cancer (CRC). Therefore, targeting HIF-1[alpha] is a promising strategy fo...
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Metabolic targeting of HIF-1[alpha] potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
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TN_cdi_gale_infotracmisc_A610864920
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A610864920
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ISSN
0950-9232
DOI
10.1038/s41388-019-0999-8
