A G.sub.s-coupled purinergic receptor boosts Ca.sup.2+ influx and vascular contractility during diab...
A G.sub.s-coupled purinergic receptor boosts Ca.sup.2+ influx and vascular contractility during diabetic hyperglycemia
About this item
Full title
Author / Creator
Publisher
eLife Science Publications, Ltd
Journal title
Language
English
Formats
Publication information
Publisher
eLife Science Publications, Ltd
Subjects
More information
Scope and Contents
Contents
Elevated glucose increases vascular reactivity by promoting L-type Ca.sub.V1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a G.sub.s-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation during diabetic hyperglycemia. Experiments in apyrase-treated cel...
Alternative Titles
Full title
A G.sub.s-coupled purinergic receptor boosts Ca.sup.2+ influx and vascular contractility during diabetic hyperglycemia
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A623699748
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A623699748
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.42214
