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Amyloidogenic processing of Alzheimer's disease [beta]-amyloid precursor protein induces cellular ir...

Amyloidogenic processing of Alzheimer's disease [beta]-amyloid precursor protein induces cellular ir...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A634552658

Amyloidogenic processing of Alzheimer's disease [beta]-amyloid precursor protein induces cellular iron retention

About this item

Full title

Amyloidogenic processing of Alzheimer's disease [beta]-amyloid precursor protein induces cellular iron retention

Publisher

Nature Publishing Group

Journal title

Molecular psychiatry, 2020-09, Vol.25 (9), p.1958

Language

English

Formats

Publication information

Publisher

Nature Publishing Group

More information

Scope and Contents

Contents

The proteolytic cleavage of [beta]-amyloid precursor protein (APP) to form the amyloid beta (A[beta]) peptide is related to the pathogenesis of Alzheimer's disease (AD) because APP mutations that influence this processing either induce familial AD or mitigate the risk of AD. Yet A[beta] formation itself may not be pathogenic. APP promotes neuronal...

Alternative Titles

Full title

Amyloidogenic processing of Alzheimer's disease [beta]-amyloid precursor protein induces cellular iron retention

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Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A634552658

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A634552658

Other Identifiers

ISSN

1359-4184

DOI

10.1038/s41380-020-0762-0

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