Mycolactone toxin induces an inflammatory response by targeting the IL-1[beta] pathway: Mechanistic...
Mycolactone toxin induces an inflammatory response by targeting the IL-1[beta] pathway: Mechanistic insight into Buruli ulcer pathophysiology
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Author / Creator
Foulon, M , Robbe-Saule, M , Manry, J , Esnault, L , Boucaud, Y , Alcaïs, A , Malloci, M , Fanton d'Andon, M , Beauvais, T , Labarriere, N , Jeannin, P , Abel, L , Saint-André, J. P , Croué, A , Delneste, Y , Boneca, I. G , Marsollier, L and Marion, E
Publisher
Public Library of Science
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English
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Publisher
Public Library of Science
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Contents
Mycolactone, a lipid-like toxin, is the major virulence factor of Mycobacterium ulcerans, the etiological agent of Buruli ulcer. Its involvement in lesion development has been widely described in early stages of the disease, through its cytotoxic and immunosuppressive activities, but less is known about later stages. Here, we revisit the role of my...
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Full title
Mycolactone toxin induces an inflammatory response by targeting the IL-1[beta] pathway: Mechanistic insight into Buruli ulcer pathophysiology
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TN_cdi_gale_infotracmisc_A650814864
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A650814864
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ISSN
1553-7366
DOI
10.1371/journal.ppat.1009107
