Microglia use TAM receptors to detect and engulf amyloid [beta] plaques
Microglia use TAM receptors to detect and engulf amyloid [beta] plaques
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Nature Publishing Group
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English
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Nature Publishing Group
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Two microglial TAM receptor tyrosine kinases, Axl and Mer, have been linked to Alzheimer's disease, but their roles in disease have not been tested experimentally. We find that in Alzheimer's disease and its mouse models, induced expression of Axl and Mer in amyloid plaque-associated microglia was coupled to induced plaque decoration by the TAM lig...
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Full title
Microglia use TAM receptors to detect and engulf amyloid [beta] plaques
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TN_cdi_gale_infotracmisc_A660672380
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A660672380
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ISSN
1529-2908
DOI
10.1038/s41590-021-00913-5
