Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
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BioMed Central Ltd
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Language
English
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BioMed Central Ltd
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Contents
Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulation, in...
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Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
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TN_cdi_gale_infotracmisc_A665424115
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A665424115
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-021-01209-3
