C/EBP[beta] is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acut...
C/EBP[beta] is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia
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Yusenko, Maria V , Trentmann, Amke , Casolari, Debora A , Abdel Ghani, Luca , Lenz, Mairin , Horn, Melanie , Dörner, Wolfgang , Klempnauer, Stefan , Mootz, Henning D , Arteaga, Maria Francisca , Mikesch, Jan-Henrik , D'Andrea, Richard J , Gonda, Thomas J , Muller-Tidow, Carsten , Schmidt, Thomas J and Klempnauer, Karl-Heinz
Publisher
Nature Publishing Group
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English
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Nature Publishing Group
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Transcription factor MYB has recently emerged as a promising drug target for the treatment of acute myeloid leukemia (AML). Here, we have characterized a group of natural sesquiterpene lactones (STLs), previously shown to suppress MYB activity, for their potential to decrease AML cell proliferation. Unlike what was initially thought, these compound...
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Full title
C/EBP[beta] is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia
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TN_cdi_gale_infotracmisc_A669343763
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A669343763
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ISSN
0950-9232
DOI
10.1038/s41388-021-01800-x
