Combine and conquer: manganese synergizing anti-TGF-[beta]/PD-L1 bispecific antibody YM101 to overco...
Combine and conquer: manganese synergizing anti-TGF-[beta]/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers
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Author / Creator
Yi, Ming , Niu, Mengke , Zhang, Jing , Li, Shiyu , Zhu, Shuangli , Yan, Yongxiang , Li, Ning , Zhou, Pengfei , Chu, Qian and Wu, Kongming
Publisher
BioMed Central Ltd
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Language
English
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BioMed Central Ltd
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Background Our previous work showed that the anti-TGF-[beta]/PD-L1 bispecific antibody YM101 effectively overcame anti-PD-L1 resistance in immune-excluded tumor models. However, in immune-desert models, the efficacy of YM101 was limited. Bivalent manganese (Mn.sup.2+) is identified as a natural stimulator of interferon genes (STING) agonist, which...
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Full title
Combine and conquer: manganese synergizing anti-TGF-[beta]/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers
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TN_cdi_gale_infotracmisc_A678013803
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A678013803
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ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-021-01155-6
