A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-[alp...
A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-[alpha]5 NAM (basmisanil) on intellectual disability associated with Down syndrome
About this item
Full title
Author / Creator
Wouldes, Trecia , Zuddas, Alessandro , Pellicer, Sabine , Redondo-Collazo, Lorenzo , Glue, Paul , Rafii, Michael S , Malagón Valdez, Jorge , Lennon-Chrimes, Sian , d'Ardhuy, Xavier Liogier , De La Torre Fornell, Rafael , Silva, Alexandra M , Mitchell, Ed A , Marshall, Andrew , Stanley, Maria , Hipp, Joerg F , Derks, Michael , Shankar, Rohit , Uhlmann, Sonja , Pulsifer, Margaret , Casero, Julian Lirio , Rebillat, Anne-Sophie , Visootsak, Jeannie , Kishnani, Priya S , Squassante, Lisa , Noeldeke, Jana , Hernandez, Maria-Clemencia , Fontoura, Paulo , Sanlaville, Damien , Zampino, Giuseppe , Goeldner, Celia , Loveday, Sarah , McDonough, Mary Ellen , Khwaja, Omar , Wandel, Christoph , Wilcox, William , Slykerman, Rebecca F , Ochoa, Cesar , Martinón-Torres, Federico , Marquez Chin, Valeria , Evans, Casey L , Michel Reynoso, Adriana G , McCary, Lindsay M , Vicari, Stefano , Skotko, Brian G , Hoover-Fong, Julie , Moldenhauer, Fernando , Sarda, Pierre , Novell, Ramon and Rodriguez-Tenreiro, Carmen
Publisher
BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Background There are currently no pharmacological therapies to address the intellectual disability associated with Down syndrome. Excitatory/inhibitory imbalance has been hypothesized to contribute to impairments in cognitive functioning in Down syndrome. Negative modulation of the GABA.sub.A-[alpha]5 receptor is proposed as a mechanism to attenuat...
Alternative Titles
Full title
A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-[alpha]5 NAM (basmisanil) on intellectual disability associated with Down syndrome
Authors, Artists and Contributors
Author / Creator
Zuddas, Alessandro
Pellicer, Sabine
Redondo-Collazo, Lorenzo
Glue, Paul
Rafii, Michael S
Malagón Valdez, Jorge
Lennon-Chrimes, Sian
d'Ardhuy, Xavier Liogier
De La Torre Fornell, Rafael
Silva, Alexandra M
Mitchell, Ed A
Marshall, Andrew
Stanley, Maria
Hipp, Joerg F
Derks, Michael
Shankar, Rohit
Uhlmann, Sonja
Pulsifer, Margaret
Casero, Julian Lirio
Rebillat, Anne-Sophie
Visootsak, Jeannie
Kishnani, Priya S
Squassante, Lisa
Noeldeke, Jana
Hernandez, Maria-Clemencia
Fontoura, Paulo
Sanlaville, Damien
Zampino, Giuseppe
Goeldner, Celia
Loveday, Sarah
McDonough, Mary Ellen
Khwaja, Omar
Wandel, Christoph
Wilcox, William
Slykerman, Rebecca F
Ochoa, Cesar
Martinón-Torres, Federico
Marquez Chin, Valeria
Evans, Casey L
Michel Reynoso, Adriana G
McCary, Lindsay M
Vicari, Stefano
Skotko, Brian G
Hoover-Fong, Julie
Moldenhauer, Fernando
Sarda, Pierre
Novell, Ramon
Rodriguez-Tenreiro, Carmen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A692027758
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A692027758
Other Identifiers
ISSN
1866-1947
DOI
10.1186/s11689-022-09418-0
