Congenital deficiency reveals critical role of ISG15 in skin homeostasis
Congenital deficiency reveals critical role of ISG15 in skin homeostasis
About this item
Full title
Author / Creator
Malik, Muhammad Nasir Hayat , Waqas, Syed Fakhar-ul-Hassnain , Zeitvogel, Jana , Cheng, Jingyuan , Geffers, Robert , Gouda, Zeinab Abu-Elbaha , Elsaman, Ahmed Mahrous , Radwan, Ahmed R , Schefzyk, Matthias , Braubach, Peter , Auber, Bernd , Olmer, Ruth , Musken, Mathias , Roesner, Lennart M , Gerold, Gisa , Schuchardt, Sven , Merkert, Sylvia , Martin, Ulrich , Meissner, Felix , Werfel, Thomas and Pessler, Frank
Publisher
American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
American Society for Clinical Investigation
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More information
Scope and Contents
Contents
Ulcerating skin lesions are manifestations of human ISG15 deficiency, a type I interferonopathy. However, chronic inflammation may not be their exclusive cause. We describe two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment. Both had a homozygous nonsense mutation in the ISG15 gene, leading to unst...
Alternative Titles
Full title
Congenital deficiency reveals critical role of ISG15 in skin homeostasis
Authors, Artists and Contributors
Author / Creator
Waqas, Syed Fakhar-ul-Hassnain
Zeitvogel, Jana
Cheng, Jingyuan
Geffers, Robert
Gouda, Zeinab Abu-Elbaha
Elsaman, Ahmed Mahrous
Radwan, Ahmed R
Schefzyk, Matthias
Braubach, Peter
Auber, Bernd
Olmer, Ruth
Musken, Mathias
Roesner, Lennart M
Gerold, Gisa
Schuchardt, Sven
Merkert, Sylvia
Martin, Ulrich
Meissner, Felix
Werfel, Thomas
Pessler, Frank
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A693733727
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A693733727
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI141573.
