Cytotoxic compounds from the root bark of Securidac alongipedunculata
Cytotoxic compounds from the root bark of Securidac alongipedunculata
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Chemical Society of Ethiopia
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English
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Chemical Society of Ethiopia
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Chromatographic separation of the ethyl acetate extract of the root bark of Securidaca longipedunculata led to the isolation of one new xanthone derivative (1) along with nine known compounds (2-10). The structure of the isolated compounds were identified by NMR, mass spectrometric analyses, and comparison with the reported literature data. The isolates were evaluated for their cytotoxic activity with compounds 5 (IC50 = 0.38 µM) and 6 (IC50 = 52 µM) showed significant inhibitory activities against the human cervical cancer KB-3-1 cell line. Compound 5 displayed superior activity, which is even better than one of the reference drugs (griseofulvin, IC50 = 17 µM), whereas the rest showed little or none inhibitory activities.
KEY WORDS: Securidaca longipedunculata, Root bark, Xanthones, Cytotoxicity, Cervical cancer
Bull. Chem. Soc. Ethiop. 2022, 36(2), 417-422.
DOI: https://dx.doi.org/10.4314/bcse.v36i2.14...
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Cytotoxic compounds from the root bark of Securidac alongipedunculata
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TN_cdi_gale_infotracmisc_A706999926
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A706999926
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ISSN
1011-3924
E-ISSN
1726-801X
DOI
10.4314/bcse.v36i2.14
