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Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A729115083

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

About this item

Full title

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Author / Creator

Publisher

Springer Spektrum

Journal title

ALTEX, alternatives to animal experimentation, 2022-01, Vol.39 (4), p.560

Language

English

Formats

Publication information

Publisher

Springer Spektrum

More information

Scope and Contents

Contents

Drug-induced neurotoxicity is a leading cause of safety-related attrition for therapeutics in clinical trials, often driven by poor predictivity of preclinical in vitro and in vivo models of neurotoxicity. Over a dozen different iPSC- derived 3D spheroids have been described in recent years, but their ability to predict neurotoxicity in patients ha...

Alternative Titles

Full title

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity

Authors, Artists and Contributors

Author / Creator

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A729115083

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A729115083

Other Identifiers

ISSN

1868-596X

E-ISSN

1868-596X

DOI

10.14573/altex.2112221

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