Macrophage depletion blocks congenital SARMI-dependent neuropathy
Macrophage depletion blocks congenital SARMI-dependent neuropathy
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Publisher
American Society for Clinical Investigation
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Language
English
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Publisher
American Society for Clinical Investigation
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Scope and Contents
Contents
Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified 2 rare NMNAT2 missense variants in 2 brothers afflicted with a progressive neuropathy syndrome. The polymorphisms resulted in amino acid substituti...
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Full title
Macrophage depletion blocks congenital SARMI-dependent neuropathy
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TN_cdi_gale_infotracmisc_A730549309
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A730549309
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI159800
