Mitochondrial dysfunction reactivates a-fetoprotein expression that drives copper-dependent immunosu...
Mitochondrial dysfunction reactivates a-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models
About this item
Full title
Author / Creator
Jett, Kimberly A , Baker, Zakery N , Hossain, Amzad , Boulet, Aren , Cobine, Paul A , Ghosh, Sagnika , Ng, Philip , Yilmaz, Orhan , Barreto, Kris , DeCoteau, John , Mochoruk, Karen , Ioannou, George N , Savard, Christopher , Yuan, Sai , Abdalla, Osama H.M.H , Lowden, Christopher , Kim, Byung-Eun , Cheng, Hai-Ying Mary , Battersby, Brendan J , Gohil, Vishal M and Leary, Scot C
Publisher
American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Signaling circuits crucial to systemic physiology are widespread, yet uncovering their molecular underpinnings remains a barrier to understanding the etiology of many metabolic disorders. Here, we identified a copper-linked signaling circuit activated by disruption of mitochondrial function in the murine liver or heart that resulted in atrophy of t...
Alternative Titles
Full title
Mitochondrial dysfunction reactivates a-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models
Authors, Artists and Contributors
Author / Creator
Baker, Zakery N
Hossain, Amzad
Boulet, Aren
Cobine, Paul A
Ghosh, Sagnika
Ng, Philip
Yilmaz, Orhan
Barreto, Kris
DeCoteau, John
Mochoruk, Karen
Ioannou, George N
Savard, Christopher
Yuan, Sai
Abdalla, Osama H.M.H
Lowden, Christopher
Kim, Byung-Eun
Cheng, Hai-Ying Mary
Battersby, Brendan J
Gohil, Vishal M
Leary, Scot C
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A734483530
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A734483530
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI154684
