Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF[sup.V60...
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF[sup.V600E] Protein
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Publisher
MDPI AG
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Language
English
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Publisher
MDPI AG
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Contents
BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAF[sup.V600E] mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resistance mechanisms. The PROTAC-induced degradation of BRAF[sup.V600E] has been proposed as an al...
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Full title
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAF[sup.V600E] Protein
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TN_cdi_gale_infotracmisc_A745960907
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A745960907
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27238513
