Intratumoral androgen biosynthesis associated with 3[beta]-hydroxysteroid dehydrogenase 1 promotes r...
Intratumoral androgen biosynthesis associated with 3[beta]-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer
About this item
Full title
Author / Creator
Ganguly, Shinjini , Lone, Zaeem , Muskara, Andrew , Imamura, Jarrell , Hardaway, Aimalie , Patel, Mona , Berk, Mike , Smile, Timothy D , Davicioni, Elai , Stephans, Kevin L , Ciezki, Jay , Weight, Christopher J , Gupta, Shilpa , Reddy, Chandana A , Tendulkar, Rahul D , Chakraborty, Abhishek A , Klein, Eric A , Sharifi, Nima and Mian, Omar Y
Publisher
American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Half of all men with advanced prostate cancer (PCa) inherit at least 1 copy of an adrenal-permissive HSD3B1 (1245C) allele, which increases levels of 3[beta]-hydroxysteroid dehydrogenase 1 (3[beta]HSD1) and promotes intracellular androgen biosynthesis. Germline inheritance of the adrenally permissive allele confers worse outcomes in men with advanc...
Alternative Titles
Full title
Intratumoral androgen biosynthesis associated with 3[beta]-hydroxysteroid dehydrogenase 1 promotes resistance to radiotherapy in prostate cancer
Authors, Artists and Contributors
Author / Creator
Lone, Zaeem
Muskara, Andrew
Imamura, Jarrell
Hardaway, Aimalie
Patel, Mona
Berk, Mike
Smile, Timothy D
Davicioni, Elai
Stephans, Kevin L
Ciezki, Jay
Weight, Christopher J
Gupta, Shilpa
Reddy, Chandana A
Tendulkar, Rahul D
Chakraborty, Abhishek A
Klein, Eric A
Sharifi, Nima
Mian, Omar Y
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A773841657
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A773841657
Other Identifiers
ISSN
0021-9738
DOI
10.1172/JCI165718
