High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal IH...
High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal IHIF2a/I/Iron-Metabolism Pathway
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Author / Creator
Zhou, Sisi , Yan, Jun , Song, Kang and Ge, Ri-Li
Publisher
MDPI AG
Journal title
Language
English
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Publisher
MDPI AG
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Contents
Excessive erythrocytosis (EE) is a preclinical form of chronic mountain sickness (CMS). The dysregulation of iron metabolism in high-altitude hypoxia may induce EE. The intestinal hypoxia-inducible factor 2 alpha (HIF2a) regulates the genes involved in iron metabolism. Considering these findings, we aimed to investigate the function and mechanism o...
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Full title
High-Altitude Hypoxia Induces Excessive Erythrocytosis in Mice via Upregulation of the Intestinal IHIF2a/I/Iron-Metabolism Pathway
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Record Identifier
TN_cdi_gale_infotracmisc_A774317628
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A774317628
Other Identifiers
ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines11112992
