Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic I...
Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic IDNAJC3/I Variants
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MDPI AG
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English
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MDPI AG
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The BiP co-chaperone DNAJC3 protects cells during ER stress. In mice, the deficiency of DNAJC3 leads to beta-cell apoptosis and the gradual onset of hyperglycemia. In humans, biallelic DNAJC3 variants cause a multisystem disease, including early-onset diabetes mellitus. Recently, hyperinsulinemic hypoglycemia (HH) has been recognized as part of thi...
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Congenital Hyperinsulinism in Humans and Insulin Secretory Dysfunction in Mice Caused by Biallelic IDNAJC3/I Variants
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TN_cdi_gale_infotracmisc_A780876797
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A780876797
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ISSN
1422-0067
DOI
10.3390/ijms25021270
