Synthesis of [[sup.11]C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Al...
Synthesis of [[sup.11]C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography
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Publisher
MDPI AG
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Language
English
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MDPI AG
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The aim of this study was to measure the brain penetrance and kinetics of BIIB104, a first-in-class AMPA receptor potentiator developed for cognitive impairment associated with schizophrenia. It was recently halted in phase 2 clinical development, and there are a lack of tools to directly measure AMPA receptor engagement. To achieve this, the drug...
Alternative Titles
Full title
Synthesis of [[sup.11]C]BIIB104, an α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic-Acid-Positive Allosteric Modulator, and Evaluation of the Bio-Distribution in Non-Human Primate Brains Using Positron Emission Tomography
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TN_cdi_gale_infotracmisc_A780880119
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A780880119
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules29020427
