Comprehensive Assessment of ICFTR/I Modulators’ Therapeutic Efficiency for N1303K Variant
Comprehensive Assessment of ICFTR/I Modulators’ Therapeutic Efficiency for N1303K Variant
About this item
Full title
Comprehensive Assessment of ICFTR/I Modulators’ Therapeutic Efficiency for N1303K Variant
Author / Creator
Publisher
MDPI AG
Journal title
International journal of molecular sciences, 2024-02, Vol.25 (5)
Language
English
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Publication information
Publisher
MDPI AG
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Scope and Contents
Contents
p.Asn1303Lys (N1303K) is a common missense variant of the CFTR gene, causing cystic fibrosis (CF). In this study, we initially evaluated the influence of CFTR modulators on the restoration of N1303K-CFTR function using intestinal organoids derived from four CF patients expressing the N1303K variant. The forskolin-induced swelling assay in organoids...
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Full title
Comprehensive Assessment of ICFTR/I Modulators’ Therapeutic Efficiency for N1303K Variant
Authors, Artists and Contributors
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Record Identifier
TN_cdi_gale_infotracmisc_A786437029
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A786437029
Other Identifiers
ISSN
1422-0067
DOI
10.3390/ijms25052770
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