An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-[beta]1...
An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-[beta]1 induced calcium response in an in vitro model of thyroid eye disease
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Chen, Qian , Pan, Yuan , Hu, Yunwei , Chen, Guanyu , Chen, Xiaoqing , Xie, Yanyan , Wang, Minzhen , Li, Zhuang , Huang, Jun , Shi, Yuxun , Huang, Haixiang , Zhang, Te , Wang, Mei , Zeng, Peng , Wang, Sha , Chen, Rongxin , Zheng, Yongxin , Zhong, Liuxueying , Yang, Huasheng and Liang, Dan
Publisher
BioMed Central Ltd
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English
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BioMed Central Ltd
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Background Thyroid eye disease (TED) is a vision-threatening autoimmune disorder. Orbital tissue fibrosis leading to intractable complications remains a troublesome issue in TED management. Exploration of novel therapeutic targets and agents to ameliorate tissue fibrosis is crucial for TED. Recent work suggests that Ca.sup.2+ signaling participates...
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Full title
An L-type calcium channel blocker nimodipine exerts anti-fibrotic effects by attenuating TGF-[beta]1 induced calcium response in an in vitro model of thyroid eye disease
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TN_cdi_gale_infotracmisc_A808333721
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A808333721
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ISSN
2326-0254
DOI
10.1186/s40662-024-00401-5
