An orally available P1'-5-fluorinated [M.sup.pro] inhibitor blocks SARS-CoV-2 replication without bo...
An orally available P1'-5-fluorinated [M.sup.pro] inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier
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Author / Creator
Higashi-Kuwata, Nobuyo , Bulut, Haydar , Hayashi, Hironori , Tsuji, Kohei , Ogata- Aoki, Hiromi , Kiso, Maki , Takamune, Nobutoki , Kishimoto, Naoki , Hattori, Shin-ichiro , Ishii, Takahiro , Kobayakawa, Takuya , Nakano, Kenta , Shimizu, Yukiko , Das, Debananda , Saruwatari, Junji , Hasegawa, Kazuya , Murayama, Kazutaka , Sukenaga, Yoshikazu , Takamatsu, Yuki , Yoshimura, Kazuhisa , Aoki, Manabu , Furusawa, Yuri , Okamura, Tadashi , Yamayoshi, Seiya , Kawaoka, Yoshihiro , Misumi, Shogo , Tamamura, Hirokazu and Mitsuya, Hiroaki
Publisher
Oxford University Press
Journal title
Language
English
Formats
Publication information
Publisher
Oxford University Press
Subjects
More information
Scope and Contents
Contents
We identified a 5-fluoro-benzothiazole-containing small molecule, TKB272, through fluorine-scanning of the benzothiazole moiety, which more potently inhibits the enzymatic activity of SARS-CoV-2's main protease ([M.sup.pro]) and more effectively blocks the infectivity and replication of all SARS-CoV-2 strains examined including Omicron variants suc...
Alternative Titles
Full title
An orally available P1'-5-fluorinated [M.sup.pro] inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier
Authors, Artists and Contributors
Author / Creator
Bulut, Haydar
Hayashi, Hironori
Tsuji, Kohei
Ogata- Aoki, Hiromi
Kiso, Maki
Takamune, Nobutoki
Kishimoto, Naoki
Hattori, Shin-ichiro
Ishii, Takahiro
Kobayakawa, Takuya
Nakano, Kenta
Shimizu, Yukiko
Das, Debananda
Saruwatari, Junji
Hasegawa, Kazuya
Murayama, Kazutaka
Sukenaga, Yoshikazu
Takamatsu, Yuki
Yoshimura, Kazuhisa
Aoki, Manabu
Furusawa, Yuri
Okamura, Tadashi
Yamayoshi, Seiya
Kawaoka, Yoshihiro
Misumi, Shogo
Tamamura, Hirokazu
Mitsuya, Hiroaki
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_gale_infotracmisc_A829860973
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A829860973
Other Identifiers
ISSN
2752-6542
E-ISSN
2752-6542
DOI
10.1093/pnasnexus/pgae578
