[alpha]-catenin ([alpha]-cat) displays force-dependent unfolding and binding to actin filaments through direct and indirect means, but features of adherens junction structure and function most vulnerable to loss of these allosteric mechanisms have not been directly compared. By reconstituting an [alpha]-cat F-actin-binding domain unfolding mutant k...

catenin middle- and actin-binding domain unfolding mutants differentially impact epithelial strength and sheet migration