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Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3K[alpha]-dependent...

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3K[alpha]-dependent...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A839382673

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3K[alpha]-dependent hepatocyte signaling

Publication information

Publisher

Public Library of Science

More information

Scope and Contents

Contents

Insulin and other growth factors are key regulators of liver gene expression, including in metabolic diseases. Most of the phosphoinositide 3-kinase (PI3K) activity induced by insulin is considered to be dependent on PI3K[alpha]. We used mice lacking p110[alpha], the catalytic subunit of PI3K[alpha], to investigate its role in the regulation of liv...

Alternative Titles

Full title

Liver gene expression and its rewiring in hepatic steatosis are controlled by PI3K[alpha]-dependent hepatocyte signaling

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_gale_infotracmisc_A839382673

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_gale_infotracmisc_A839382673

Other Identifiers

ISSN

1544-9173

DOI

10.1371/journal.pbio.3003112

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