Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibrobla...
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumourchemoresistance
About this item
Full title
Author / Creator
Duluc, Camille , Moatassim-Billah, Siham , Chalabi-Dchar, Mounira , Perraud, Aurélie , Samain, Rémi , Breibach, Florence , Gayral, Marion , Cordelier, Pierre , Delisle, Marie-Bernadette , Bousquet-Dubouch, Marie-Pierre , Tomasini, Richard , Schmid, Herbert , Mathonnet, Muriel , Pyronnet, Stéphane , Martineau, Yvan and Bousquet, Corinne
Publisher
Wiley Open Access
Journal title
Language
English
Formats
Publication information
Publisher
Wiley Open Access
Subjects
More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma-rich. Cancer-associated fibroblasts (CAFs) secrete proteins that activate survival and promote chemoresistance of cancer cells. Our results demonstrate that CAF secretome-triggered chemoresistance is abolished upon inhibition of the protein synthesis mTOR/4E-BP1 regulatory pathway which we...
Alternative Titles
Full title
Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumourchemoresistance
Authors, Artists and Contributors
Author / Creator
Moatassim-Billah, Siham
Chalabi-Dchar, Mounira
Perraud, Aurélie
Samain, Rémi
Breibach, Florence
Gayral, Marion
Cordelier, Pierre
Delisle, Marie-Bernadette
Bousquet-Dubouch, Marie-Pierre
Tomasini, Richard
Schmid, Herbert
Mathonnet, Muriel
Pyronnet, Stéphane
Martineau, Yvan
Bousquet, Corinne
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_01208071v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01208071v1
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201404346
