Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, doub...
Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial
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Author / Creator
Meininger, Vincent, MD , Genge, Angela, MD , van den Berg, Leonard H, Prof , Robberecht, Wim, Prof , Ludolph, Albert, Prof , Chio, Adriano, Prof , Kim, Seung H, Prof , Leigh, P Nigel, Prof , Kiernan, Matthew C, Prof , Shefner, Jeremy M, Prof , Desnuelle, Claude, Prof , Morrison, Karen E, Prof , Petri, Susanne, Prof , Boswell, Diane, BSc , Temple, Jane, PhD , Mohindra, Rajat, MD , Davies, Matt, MSc , Bullman, Jonathan, BSc , Rees, Paul, PhD , Lavrov, Arseniy, Dr and NOG112264 Study Group
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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Scope and Contents
Contents
Summary Background Neurite outgrowth inhibitor A (Nogo-A) is thought to have a role in the pathophysiology of amyotrophic lateral sclerosis (ALS). A monoclonal antibody against Nogo-A showed a positive effect in the SOD1G93A mouse model of ALS, and a humanised form of this antibody (ozanezumab) was well tolerated in a first-in-human trial. Therefor...
Alternative Titles
Full title
Safety and efficacy of ozanezumab in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled, phase 2 trial
Authors, Artists and Contributors
Author / Creator
Genge, Angela, MD
van den Berg, Leonard H, Prof
Robberecht, Wim, Prof
Ludolph, Albert, Prof
Chio, Adriano, Prof
Kim, Seung H, Prof
Leigh, P Nigel, Prof
Kiernan, Matthew C, Prof
Shefner, Jeremy M, Prof
Desnuelle, Claude, Prof
Morrison, Karen E, Prof
Petri, Susanne, Prof
Boswell, Diane, BSc
Temple, Jane, PhD
Mohindra, Rajat, MD
Davies, Matt, MSc
Bullman, Jonathan, BSc
Rees, Paul, PhD
Lavrov, Arseniy, Dr
NOG112264 Study Group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_01785450v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01785450v1
Other Identifiers
ISSN
1474-4422,1474-4465
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(16)30399-4
