An allosteric modulator to control endogenous G protein-coupled receptors with light
An allosteric modulator to control endogenous G protein-coupled receptors with light
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Alloswitch-1 is a photoswitchable modulator for mGlu5, and it is the first photoswitchable allosteric GPCR modulator. It was generated by adding the azobenzene Ar-N=N-Ar scaffold into an existing positive allosteric modulator of the receptor.
Controlling drug activity with light offers the possibility of enhancing pharmacological selectivity wit...
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Full title
An allosteric modulator to control endogenous G protein-coupled receptors with light
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Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_01942934v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01942934v1
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1612
