Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base m...
Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Somatic activating mutations of smoothened (SMO), a component of the embryonic sonic hedgehog (SHH) signaling pathway, are found in 3–5% of grade I meningiomas, most of them corresponding to meningothelial meningiomas located at the anterior skull base. By generating different developmental stage-specific conditional activations in mice, we define...
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Full title
Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation
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TN_cdi_hal_primary_oai_HAL_hal_01991334v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_01991334v1
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-018-0328-7
