Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specificall...
Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium
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Author / Creator
Le Meur, G , Stieger, K , Smith, A J , Weber, M , Deschamps, J Y , Nivard, D , Mendes-Madeira, A , Provost, N , Péréon, Y , Cherel, Y , Ali, R R , Hamel, C , Moullier, P and Rolling, F
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Previous studies have tested gene replacement therapy in RPE65-deficient dogs using recombinant adeno-associated virus 2/2 (rAAV2/2), -2/1 or -2/5 mediated delivery of the RPE65 gene. They all documented restoration of dark- and light-adapted electroretinography responses and improved psychophysical outcomes. Use of a specific RPE65 promoter and a...
Alternative Titles
Full title
Restoration of vision in RPE65-deficient Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_02666207v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02666207v1
Other Identifiers
ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/sj.gt.3302861
