Large-Scale Manufacture and Characterization of a Lentiviral Vector Produced for Clinical Ex Vivo Ge...
Large-Scale Manufacture and Characterization of a Lentiviral Vector Produced for Clinical Ex Vivo Gene Therapy Application
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Full title
Author / Creator
Publisher
Larchmont, NY: Liebert
Journal title
Language
English
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Publisher
Larchmont, NY: Liebert
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Scope and Contents
Contents
From the perspective of a pilot clinical gene therapy trial for Wiskott-Aldrich syndrome (WAS), we implemented a process to produce a lentiviral vector under good manufacturing practices (GMP). The process is based on the transient transfection of 293T cells in Cell Factory stacks, scaled up to harvest 50 liters of viral stock per batch, followed b...
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Full title
Large-Scale Manufacture and Characterization of a Lentiviral Vector Produced for Clinical Ex Vivo Gene Therapy Application
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Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_02881193v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02881193v1
Other Identifiers
ISSN
1043-0342
E-ISSN
1557-7422,1043-0342
DOI
10.1089/hum.2010.060
