Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-posit...
Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): a randomised, open-label, multicentre, phase 2 trial
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Author / Creator
Cortés, Javier, Dr , Dieras, Véronique, MD , Ro, Jungsil, MD , Barriere, Jérôme, MD , Bachelot, Thomas, MD , Hurvitz, Sara, MD , Le Rhun, Emilie, MD , Espié, Marc, MD , Kim, Sung-Bae, MD , Schneeweiss, Andreas, MD , Sohn, Joo Hyuk, MD , Nabholtz, Jean-Marc, Prof , Kellokumpu-Lehtinen, Pirkko-Liisa, Prof , Taguchi, Julie, MD , Piacentini, Federico, MD , Ciruelos, Eva, MD , Bono, Petri, MD , Ould-Kaci, Mahmoud, MD , Roux, Flavien, MSc and Joensuu, Heikki, Prof
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
Subjects
More information
Scope and Contents
Contents
Summary Background Patients with advanced HER2-positive breast cancer frequently develop CNS metastases. The metastases that progress after brain radiotherapy and HER2-targeted systemic therapy are a difficult therapeutic challenge. We aimed to assess the efficacy and safety of afatinib, an irreversible blocker of the ErbB protein family, alone or...
Alternative Titles
Full title
Afatinib alone or afatinib plus vinorelbine versus investigator's choice of treatment for HER2-positive breast cancer with progressive brain metastases after trastuzumab, lapatinib, or both (LUX-Breast 3): a randomised, open-label, multicentre, phase 2 trial
Authors, Artists and Contributors
Author / Creator
Dieras, Véronique, MD
Ro, Jungsil, MD
Barriere, Jérôme, MD
Bachelot, Thomas, MD
Hurvitz, Sara, MD
Le Rhun, Emilie, MD
Espié, Marc, MD
Kim, Sung-Bae, MD
Schneeweiss, Andreas, MD
Sohn, Joo Hyuk, MD
Nabholtz, Jean-Marc, Prof
Kellokumpu-Lehtinen, Pirkko-Liisa, Prof
Taguchi, Julie, MD
Piacentini, Federico, MD
Ciruelos, Eva, MD
Bono, Petri, MD
Ould-Kaci, Mahmoud, MD
Roux, Flavien, MSc
Joensuu, Heikki, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_02939610v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02939610v1
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(15)00373-3
