A modular DNA scaffold to study protein–protein interactions at single-molecule resolution
A modular DNA scaffold to study protein–protein interactions at single-molecule resolution
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The residence time of a drug on its target has been suggested as a more pertinent metric of therapeutic efficacy than the traditionally used affinity constant. Here, we introduce junctured-DNA tweezers as a generic platform that enables real-time observation, at the single-molecule level, of biomolecular interactions. This tool corresponds to a dou...
Alternative Titles
Full title
A modular DNA scaffold to study protein–protein interactions at single-molecule resolution
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_02996749v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_02996749v1
Other Identifiers
ISSN
1748-3387
E-ISSN
1748-3395
DOI
10.1038/s41565-019-0542-7
