IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing ant...
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
About this item
Full title
Author / Creator
Leborgne, Christian , Barbon, Elena , Alexander, Jeffrey M. , Hanby, Hayley , Delignat, Sandrine , Cohen, Daniel M. , Collaud, Fanny , Muraleetharan, Saghana , Lupo, Dan , Silverberg, Joseph , Huang, Karen , van Wittengerghe, Laetitia , Marolleau, Béatrice , Miranda, Adeline , Fabiano, Anna , Daventure, Victoria , Beck, Heena , Anguela, Xavier M. , Ronzitti, Giuseppe , Armour, Sean M. , Lacroix-Desmazes, Sebastien and Mingozzi, Federico
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Neutralizing antibodies to adeno-associated virus (AAV) vectors are highly prevalent in humans
1
,
2
, and block liver transduction
3
–
5
and vector readministration
6
; thus, they represent a major limitation to in vivo gene therapy. Strategies aimed at overcoming anti-AAV antibodies are being studied
7
, which...
Alternative Titles
Full title
IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies
Authors, Artists and Contributors
Author / Creator
Barbon, Elena
Alexander, Jeffrey M.
Hanby, Hayley
Delignat, Sandrine
Cohen, Daniel M.
Collaud, Fanny
Muraleetharan, Saghana
Lupo, Dan
Silverberg, Joseph
Huang, Karen
van Wittengerghe, Laetitia
Marolleau, Béatrice
Miranda, Adeline
Fabiano, Anna
Daventure, Victoria
Beck, Heena
Anguela, Xavier M.
Ronzitti, Giuseppe
Armour, Sean M.
Lacroix-Desmazes, Sebastien
Mingozzi, Federico
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03031762v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03031762v1
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X,1744-7933
DOI
10.1038/s41591-020-0911-7
