RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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In acute promyelocytic leukaemia (APL), the promyelocytic leukaemia (PML) protein is fused to the retinoic acid receptor α (RAR). This disease can be treated effectively with arsenic, which induces PML modification by small ubiquitin-like modifiers (SUMO) and proteasomal degradation. Here we demonstrate that the RING-domain-containing ubiquitin E3...
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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
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TN_cdi_hal_primary_oai_HAL_hal_03082499v1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03082499v1
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb1716
