Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta...
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing
About this item
Full title
Author / Creator
Kunkle, B. W. , Grenier-Boley, B. , Sims, R. , Bis, J. C. , Damotte, V. , Naj, A. C. , Boland, A. , Vronskaya, M. , van Der Lee, S. J. , Amlie-Wolf, A. , Bellenguez, C. , Frizatti, A. , Chouraki, V. , Martin, E. R. , Sleegers, K. , Badarinarayan, N. , Jakobsdottir, J. , Hamilton-Nelson, K. L. , Moreno-Grau, S. , Olaso, R. , Raybould, R. , Chen, Y. , Kuzma, A. B. , Hiltunen, M. , Morgan, T. , Ahmad, S. , Vardarajan, B. N. , Epelbaum, J. , Hoffmann, P. , Boada, M. , Beecham, G. W. , Garnier, J. G. , Harold, D. , Fitzpatrick, A. L. , Valladares, O. , Moutet, M. L. , Gerrish, A. , Qu, L. , Bacq, D. , Denning, N. , Jian, X. , Zhao, Y. , del Zompo, M. , Fox, N. C. , Choi, S. H. , Mateo, I. , Hughes, J. T. , Adams, H. H. , Malamon, J. , Sanchez-Garcia, F. , Patel, Y. , Brody, J. A. , Dombroski, B. A. , Naranjo, M. C. D. , Daniilidou, M. , Eiriksdottir, G. , Mukherjee, S. , Wallon, D. , Uphill, J. , Aspelund, T. , Cantwell, L. B. , Garzia, F. , Galimberti, D. , Hofer, E. , Butkiewicz, M. , Fin, B. , Scarpini, E. , Sarnowski, C. , Bush, W. S. , Meslage, S. , Kornhuber, J. , White, C. C. , Song, Y. , Barber, R. C. , Engelborghs, S. , Sordon, S. , Voijnovic, D. , Adams, P. M. , Vandenberghe, R. , Mayhaus, M. , Cupples, L. A. , Albert, M. S. , de Deyn, P. P. , Gu, W. , Himali, J. J. , Beekly, D. , Squassina, A. , Hartmann, A. M. , Orellana, A. , Blacker, D. , Rodriguez-Rodriguez, E. , Lovestone, S. , Garcia, M. E. , Doody, R. S. , Munoz-Fernadez, C. , Sussams, R. , Lin, H. , Fairchild, T. J. , Benito, Y. A. and Holmes, C.
Publisher
Nature Publishing Group
Journal title
Language
English
Formats
Publication information
Publisher
Nature Publishing Group
Subjects
More information
Scope and Contents
Contents
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMT...
Alternative Titles
Full title
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing
Authors, Artists and Contributors
Author / Creator
Grenier-Boley, B.
Sims, R.
Bis, J. C.
Damotte, V.
Naj, A. C.
Boland, A.
Vronskaya, M.
van Der Lee, S. J.
Amlie-Wolf, A.
Bellenguez, C.
Frizatti, A.
Chouraki, V.
Martin, E. R.
Sleegers, K.
Badarinarayan, N.
Jakobsdottir, J.
Hamilton-Nelson, K. L.
Moreno-Grau, S.
Olaso, R.
Raybould, R.
Chen, Y.
Kuzma, A. B.
Hiltunen, M.
Morgan, T.
Ahmad, S.
Vardarajan, B. N.
Epelbaum, J.
Hoffmann, P.
Boada, M.
Beecham, G. W.
Garnier, J. G.
Harold, D.
Fitzpatrick, A. L.
Valladares, O.
Moutet, M. L.
Gerrish, A.
Qu, L.
Bacq, D.
Denning, N.
Jian, X.
Zhao, Y.
del Zompo, M.
Fox, N. C.
Choi, S. H.
Mateo, I.
Hughes, J. T.
Adams, H. H.
Malamon, J.
Sanchez-Garcia, F.
Patel, Y.
Brody, J. A.
Dombroski, B. A.
Naranjo, M. C. D.
Daniilidou, M.
Eiriksdottir, G.
Mukherjee, S.
Wallon, D.
Uphill, J.
Aspelund, T.
Cantwell, L. B.
Garzia, F.
Galimberti, D.
Hofer, E.
Butkiewicz, M.
Fin, B.
Scarpini, E.
Sarnowski, C.
Bush, W. S.
Meslage, S.
Kornhuber, J.
White, C. C.
Song, Y.
Barber, R. C.
Engelborghs, S.
Sordon, S.
Voijnovic, D.
Adams, P. M.
Vandenberghe, R.
Mayhaus, M.
Cupples, L. A.
Albert, M. S.
de Deyn, P. P.
Gu, W.
Himali, J. J.
Beekly, D.
Squassina, A.
Hartmann, A. M.
Orellana, A.
Blacker, D.
Rodriguez-Rodriguez, E.
Lovestone, S.
Garcia, M. E.
Doody, R. S.
Munoz-Fernadez, C.
Sussams, R.
Lin, H.
Fairchild, T. J.
Benito, Y. A.
Holmes, C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03209563v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03209563v1
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0358-2
