Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in o...
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
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Publisher
Wiley Open Access
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Language
English
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Publisher
Wiley Open Access
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Contents
PIKfyve is an evolutionarily conserved lipid kinase that regulates pleiotropic cellular functions. Here, we identify PIKfyve as a key regulator of cardiometabolic status and mitochondrial integrity in chronic diet-induced obesity. In vitro, we show that PIKfyve is critical for the control of mitochondrial fragmentation and hypertrophic and apoptoti...
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Full title
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
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TN_cdi_hal_primary_oai_HAL_hal_03264760v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03264760v1
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ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201607096
