Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Aneuploidy is found in most solid tumours, but it remains unclear whether it is the cause or the consequence of tumorigenesis. Using
Plk4
overexpression (PLK4OE) during epidermal development, we assess the impact of centrosome amplification and aneuploidy on skin development and tumorigenesis. PLK4OE in the developing epidermis induced centro...
Alternative Titles
Full title
Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis
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TN_cdi_hal_primary_oai_HAL_hal_03453028v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03453028v1
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3270
