Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
About this item
Full title
Author / Creator
Lock, F E , McDonald, P C , Lou, Y , Serrano, I , Chafe, S C , Ostlund, C , Aparicio, S , Winum, J-Y , Supuran, C T and Dedhar, S
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
The sub-population of tumor cells termed ‘cancer stem cells’ (CSCs) possess the capability to generate tumors, undergo epithelial–mesenchymal transition (EMT) and are implicated in metastasis, making treatments to specifically target CSCs an attractive therapeutic strategy. Tumor hypoxia plays a key role in regulating EMT and cancer stem cell funct...
Alternative Titles
Full title
Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03617832v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03617832v1
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2012.550
