Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial...
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
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Author / Creator
Italiano, A. , Bessede, A. , Pulido, M. , Bompas, E. , Piperno-Neumann, S. , Chevreau, C. , Penel, N. , Bertucci, F. , Toulmonde, M. , Bellera, C. , Guegan, J. P. , Rey, C. , Sautès-Fridman, C. , Bougoüin, A. , Cantarel, C. , Kind, M. , Spalato, M. , Dadone-Montaudie, B. , Le Loarer, F. , Blay, J. Y. and Fridman, W. H.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Immune checkpoint inhibitors (ICIs) show limited clinical activity in patients with advanced soft-tissue sarcomas (STSs). Retrospective analysis suggests that intratumoral tertiary lymphoid structures (TLSs) are associated with improved outcome in these patients. PEMBROSARC is a multicohort phase 2 study of pembrolizumab combined with low-dose cycl...
Alternative Titles
Full title
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
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Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03721377v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03721377v1
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X,1744-7933
DOI
10.1038/s41591-022-01821-3
