Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mu...
Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial
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Author / Creator
Bidard, François-Clément, Prof , Hardy-Bessard, Anne-Claire, MD , Dalenc, Florence, Prof , Bachelot, Thomas, MD , Pierga, Jean-Yves, Prof , de la Motte Rouge, Thibault, MD , Sabatier, Renaud, MD , Dubot, Coraline, MD , Frenel, Jean-Sébastien, MD , Ferrero, Jean Marc, Prof , Ladoire, Sylvain, Prof , Levy, Christelle, MD , Mouret-Reynier, Marie-Ange, MD , Lortholary, Alain, MD , Grenier, Julien, MD , Chakiba, Camille, MD , Stefani, Laetitia, MD , Plaza, Jérôme Edouard, MD , Clatot, Florian, Prof , Teixeira, Luis, Prof , D'Hondt, Véronique, MD , Vegas, Hélène, MD , Derbel, Olfa, MD , Garnier-Tixidre, Claire, MD , Canon, Jean-Luc, MD , Pistilli, Barbara, MD , André, Fabrice, Prof , Arnould, Laurent, MD , Pradines, Anne, PhD , Bièche, Ivan, Prof , Callens, Céline, PharmD , Lemonnier, Jérôme, PhD , Berger, Frédérique, MSc , Delaloge, Suzette, MD and PADA-1 investigators
Publisher
England: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
England: Elsevier Ltd
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More information
Scope and Contents
Contents
SummaryBackgroundIn advanced oestrogen receptor-positive, HER2-negative breast cancer, acquired resistance to aromatase inhibitors frequently stems from ESR1-mutated subclones, which might be sensitive to fulvestrant. The PADA-1 trial aimed to show the efficacy of an early change in therapy on the basis of a rising ESR1 mutation in blood (b ESR1mut...
Alternative Titles
Full title
Switch to fulvestrant and palbociclib versus no switch in advanced breast cancer with rising ESR1 mutation during aromatase inhibitor and palbociclib therapy (PADA-1): a randomised, open-label, multicentre, phase 3 trial
Authors, Artists and Contributors
Author / Creator
Hardy-Bessard, Anne-Claire, MD
Dalenc, Florence, Prof
Bachelot, Thomas, MD
Pierga, Jean-Yves, Prof
de la Motte Rouge, Thibault, MD
Sabatier, Renaud, MD
Dubot, Coraline, MD
Frenel, Jean-Sébastien, MD
Ferrero, Jean Marc, Prof
Ladoire, Sylvain, Prof
Levy, Christelle, MD
Mouret-Reynier, Marie-Ange, MD
Lortholary, Alain, MD
Grenier, Julien, MD
Chakiba, Camille, MD
Stefani, Laetitia, MD
Plaza, Jérôme Edouard, MD
Clatot, Florian, Prof
Teixeira, Luis, Prof
D'Hondt, Véronique, MD
Vegas, Hélène, MD
Derbel, Olfa, MD
Garnier-Tixidre, Claire, MD
Canon, Jean-Luc, MD
Pistilli, Barbara, MD
André, Fabrice, Prof
Arnould, Laurent, MD
Pradines, Anne, PhD
Bièche, Ivan, Prof
Callens, Céline, PharmD
Lemonnier, Jérôme, PhD
Berger, Frédérique, MSc
Delaloge, Suzette, MD
PADA-1 investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03867802v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03867802v1
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(22)00555-1
