Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamic...
Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study
About this item
Full title
Author / Creator
Gurjar, Rohan , Dickinson, Laura , Carr, Daniel , Stöhr, Wolfgang , Bonora, Stefano , Owen, Andrew , D’Avolio, Antonio , Cursley, Adam , De Castro, Nathalie , Fätkenheuer, Gerd , Vandekerckhove, Linos , Di Perri, Giovanni , Pozniak, Anton , Schwimmer, Christine , Raffi, François , Boffito, Marta , the NEAT001/ANRS143 Study Group and NEAT001/ANRS143 Study Group
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Using concentration-time data from the NEAT001/ARNS143 study (single sample at week 4 and 24), we determined raltegravir pharmacokinetic parameters using nonlinear mixed effects modelling (NONMEM v.7.3; 602 samples from 349 patients) and investigated the influence of demographics and SNPs (
SLC22A6
and
UGT1A1
) on raltegravir pharmacoki...
Alternative Titles
Full title
Influence of UGT1A1 and SLC22A6 polymorphisms on the population pharmacokinetics and pharmacodynamics of raltegravir in HIV-infected adults: a NEAT001/ANRS143 sub-study
Authors, Artists and Contributors
Author / Creator
Dickinson, Laura
Carr, Daniel
Stöhr, Wolfgang
Bonora, Stefano
Owen, Andrew
D’Avolio, Antonio
Cursley, Adam
De Castro, Nathalie
Fätkenheuer, Gerd
Vandekerckhove, Linos
Di Perri, Giovanni
Pozniak, Anton
Schwimmer, Christine
Raffi, François
Boffito, Marta
the NEAT001/ANRS143 Study Group
NEAT001/ANRS143 Study Group
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03887832v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03887832v1
Other Identifiers
ISSN
1470-269X
E-ISSN
1473-1150
DOI
10.1038/s41397-022-00293-5
