Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
About this item
Full title
Author / Creator
Thaiss, Christoph A , Levy, Maayan , Grosheva, Inna , Zheng, Danping , Soffer, Eliran , Blacher, Eran , Braverman, Sofia , Tengeler, Anouk C , Barak, Oren , Elazar, Maya , Ben-Zeev, Rotem , Lehavi-Regev, Dana , Katz, Meirav N , Pevsner-Fischer, Meirav , Gertler, Arieh , Halpern, Zamir , Harmelin, Alon , Aamar, Suhail , Serradas, Patricia , Grosfeld, Alexandra , Shapiro, Hagit , Geiger, Benjamin and Elinav, Eran
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Obesity, diabetes, and related manifestations are associated with an enhanced, but poorly understood, risk for mucosal infection and systemic inflammation. Here, we show in mouse models of obesity and diabetes that hyperglycemia drives intestinal barrier permeability, through GLUT2-dependent transcriptional reprogramming of intestinal epithelial ce...
Alternative Titles
Full title
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
Authors, Artists and Contributors
Author / Creator
Levy, Maayan
Grosheva, Inna
Zheng, Danping
Soffer, Eliran
Blacher, Eran
Braverman, Sofia
Tengeler, Anouk C
Barak, Oren
Elazar, Maya
Ben-Zeev, Rotem
Lehavi-Regev, Dana
Katz, Meirav N
Pevsner-Fischer, Meirav
Gertler, Arieh
Halpern, Zamir
Harmelin, Alon
Aamar, Suhail
Serradas, Patricia
Grosfeld, Alexandra
Shapiro, Hagit
Geiger, Benjamin
Elinav, Eran
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_03972757v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_03972757v1
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.aar3318
