TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter
TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter
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Publisher
MDPI
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Language
English
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MDPI
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Contents
Background: Chief among mechanisms of telomerase reverse transcriptase (TERT) reactivation is the appearance of mutations in the TERT promoter. The two main TERT promoter mutations are C>T transitions located −146C>T and −124C>T upstream from the translational start site. They generate a novel Ets/TCF binding site. Both mutations are mutually exclu...
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Full title
TERT Promoter Mutations Increase Sense and Antisense Transcription from the TERT Promoter
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TN_cdi_hal_primary_oai_HAL_hal_04484418v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04484418v1
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ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines9121773
