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Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04510220v1

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Immune checkpoint inhibitors (ICI) have transformed the therapeutic landscape in oncology. However, ICI can induce uncommon life-threatening autoimmune T-cell-mediated myotoxicities, including myocarditis and myositis. The thymus plays a critical role in T cell maturation. Here we demonstrate that thymic alterations are associated with increased in...

Alternative Titles

Full title

Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_hal_primary_oai_HAL_hal_04510220v1

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04510220v1

Other Identifiers

ISSN

1078-8956

E-ISSN

1546-170X,1744-7933

DOI

10.1038/s41591-023-02591-2

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