Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous c...
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
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Author / Creator
Sun, Xu-Shan, MD , Tao, Yungan, MD , Le Tourneau, Christophe, Prof , Pointreau, Yoann, MD , Sire, Christian, MD , Kaminsky, Marie-Christine, MD , Coutte, Alexandre, MD , Alfonsi, Marc, MD , Boisselier, Pierre, MD , Martin, Laurent, MD , Miroir, Jessica, MD , Ramee, Jean-Francois, MD , Delord, Jean-Pierre, Prof , Clatot, Florian, MD , Rolland, Frederic, MD , Villa, Julie, MD , Magne, Nicolas, MD , Elicin, Olgun, MD , Gherga, Elisabeta, MD , Nguyen, France, MD , Lafond, Cedrick, MD , Bera, Guillaume, MD , Calugaru, Valentin, MD , Geoffrois, Lionnel, MD , Chauffert, Bruno, MD , Zubel, Angela, MD , Zanna, Claudio, MD , Brienza, Silvano, MD , Crompton, Philippa, MSc , Rouits, Elisabeth, PharmD , Gollmer, Kathrin, PhD , Szyldergemajn, Sergio, MD and Bourhis, Jean, Prof
Publisher
London: Elsevier Ltd
Journal title
Language
English
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Publication information
Publisher
London: Elsevier Ltd
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Scope and Contents
Contents
SummaryBackgroundDebio 1143 is an orally available antagonist of inhibitor of apoptosis proteins with the potential to enhance the antitumour activity of cisplatin and radiotherapy. The radiosensitising effect of Debio 1143 is mediated through caspase activation and TNF, IFNγ, CD8 T cell-dependent pathways. We aimed to investigate the efficacy and...
Alternative Titles
Full title
Debio 1143 and high-dose cisplatin chemoradiotherapy in high-risk locoregionally advanced squamous cell carcinoma of the head and neck: a double-blind, multicentre, randomised, phase 2 study
Authors, Artists and Contributors
Author / Creator
Tao, Yungan, MD
Le Tourneau, Christophe, Prof
Pointreau, Yoann, MD
Sire, Christian, MD
Kaminsky, Marie-Christine, MD
Coutte, Alexandre, MD
Alfonsi, Marc, MD
Boisselier, Pierre, MD
Martin, Laurent, MD
Miroir, Jessica, MD
Ramee, Jean-Francois, MD
Delord, Jean-Pierre, Prof
Clatot, Florian, MD
Rolland, Frederic, MD
Villa, Julie, MD
Magne, Nicolas, MD
Elicin, Olgun, MD
Gherga, Elisabeta, MD
Nguyen, France, MD
Lafond, Cedrick, MD
Bera, Guillaume, MD
Calugaru, Valentin, MD
Geoffrois, Lionnel, MD
Chauffert, Bruno, MD
Zubel, Angela, MD
Zanna, Claudio, MD
Brienza, Silvano, MD
Crompton, Philippa, MSc
Rouits, Elisabeth, PharmD
Gollmer, Kathrin, PhD
Szyldergemajn, Sergio, MD
Bourhis, Jean, Prof
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04532615v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04532615v1
Other Identifiers
ISSN
1470-2045
E-ISSN
1474-5488
DOI
10.1016/S1470-2045(20)30327-2
