SSR180711, a novel selective alpha 7 nicotinic receptor partial agonist: (I) binding and functional...
SSR180711, a novel selective alpha 7 nicotinic receptor partial agonist: (I) binding and functional profile
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Author / Creator
Biton, Bruno , Bergis, Olivier E. , Galli, Frédéric , Nedelec, Alain , Lochead, Alistair W. , Jegham, Samir , Godet, Danielle , Lanneau, Christophe , Santamaria, Raphaël , Chesney, Françoise , Leonardon, Jacques , Granger, Pascal , Debono, Marc W. , Bohme, Georg A. , Sgard, Frédéric , Besnard, François , Graham, David , Coste, Annick , Oblin, André , Curet, Olivier , Vige, Xavier , Voltz, Corinne , Rouquier, Liliane , Souilhac, Josiane , Santucci, Vincent , Gueudet, Christiane , Francon, Dominique , Steinberg, Régis , Griebel, Guy , Oury-Donat, Florence , George, Pascal , Avenet, Patrick and Scatton, Bernard
Publisher
Nature Publishing Group
Journal title
Language
English
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Publication information
Publisher
Nature Publishing Group
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More information
Scope and Contents
Contents
In this paper, we report on the pharmacological and functional profile of SSR180711 (1,4-Diazabicyclo[3.2.2]nonane-4-carboxylic acid, 4-bromophenyl ester), a new selective α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. SSR180711 displays high affinity for rat and human α7 n-AChRs (Ki of 22±4 and 14±1 nM, respectively). Ex vivo 3[H]α...
Alternative Titles
Full title
SSR180711, a novel selective alpha 7 nicotinic receptor partial agonist: (I) binding and functional profile
Authors, Artists and Contributors
Author / Creator
Bergis, Olivier E.
Galli, Frédéric
Nedelec, Alain
Lochead, Alistair W.
Jegham, Samir
Godet, Danielle
Lanneau, Christophe
Santamaria, Raphaël
Chesney, Françoise
Leonardon, Jacques
Granger, Pascal
Debono, Marc W.
Bohme, Georg A.
Sgard, Frédéric
Besnard, François
Graham, David
Coste, Annick
Oblin, André
Curet, Olivier
Vige, Xavier
Voltz, Corinne
Rouquier, Liliane
Souilhac, Josiane
Santucci, Vincent
Gueudet, Christiane
Francon, Dominique
Steinberg, Régis
Griebel, Guy
Oury-Donat, Florence
George, Pascal
Avenet, Patrick
Scatton, Bernard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_hal_primary_oai_HAL_hal_04562615v1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_hal_primary_oai_HAL_hal_04562615v1
Other Identifiers
ISSN
0893-133X
E-ISSN
0007-0920
DOI
10.1038/sj.npp.1301189
